The Persian ruling house that reigned from 1501, beginning with Shah Ismail, into the 1730s, whose court patronage of painting, calligraphy and weaving made this the golden age of Persian rugs. Many museum and top-auction masterpieces come from the era, with Tabriz, Herat, Kashan and Kerman the largest centers. As patterns grew more complex, designers, often miniature painters, became separate from the weavers who worked from their drawings; the large central medallion, curvilinear and geometric layouts and richer flowers and vines became hallmarks, and patterns were standardized for export to Asian and European markets. The Afghan invasion of Isfahan in 1722 interrupted weaving in the main manufacturing centers for several years, though tribes and villages carried on.